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Taking antacids, sucralfate, or vitamin or mineral supplements too close to a dose can greatly decrease the effects of the antibiotic. Take on an empty stomach 1 hour before or 2 hours after meals. If you have any of these conditions, you may not be able to use Floxin, or you may need a dosage adjustment or special tests during treatment. 60 Minutes did an expose on the drug Floxin in 1998, showing that the under 1 of people dalsi den doruceni floxin who. With the Floxin, and my culture from the lab was negative for a UTI. Floxin tablets should be used with caution under these conditions.