Clinical Studies Bipolar Disorder Depression The efficacy of SEROQUEL for the treatment of depressive episodes associated with bipolar disorder was established in identical 8-week, randomized, double-blind, placebo-controlled studies 1045. Most patients who overdosed experienced no adverse reactions or recovered fully from the reported reactions. The topamax seroquel serequel, along with Ambien CR, is the only way can get normal night sleep. The structural formula is: Quetiapine fumarate is white to off-white crystalline powder which is moderately soluble in water. Patients with these diagnoses were excluded from premarketing clinical studies.